Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland.

doi:10.1136/vr.140.3.59

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Article

Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland.

The Veterinary record - 18 Jan 1997

Hunter N, Moore L, Hosie B D, Dingwall W S, Greig A

Abstract excerpt

The incidence of natural scrapie in sheep is associated with polymorphisms of the PrP gene, particularly those at codons 136, 154 and 171. In many breeds, the PrP allele encoding valine at codon 136 confers an extremely high risk of scrapie, but in Suffolk sheep this allele is vanishingly rare. I...

Topics

Alleles
Animals
Arginine
Base Sequence
DNA Primers
DNA, Viral
Female
Gene Frequency
Genes, Recessive
Genetic Linkage
Genotype
Glutamine
Homozygote
Immunity, Innate
Incidence
Male
Pedigree
Polymerase Chain Reaction

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