Article
Amino acid polymorphisms of PrP with reference to onset of scrapie in Suffolk and Corriedale sheep in Japan.
The Journal of general virology - 1 Oct 1995
Ikeda T, Horiuchi M, Ishiguro N, Muramatsu Y, Kai-Uwe G D, Shinagawa M
Abstract excerpt
We investigated the relationships between amino acid polymorphisms of the prion protein (PrP), restriction fragment length polymorphisms (RFLP) of the PrP gene and the incidence of natural scrapie in Japan. Six variant alleles of the PrP gene were found in healthy sheep. Based on the substitution...
Topics
- Alleles
- Amino Acids
- Animals
- Base Sequence
- Disease Susceptibility
- Genotype
- Incidence
- Japan
- Molecular Sequence Data
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- PrPSc Proteins
- Prions
- Scrapie
- Sequence Analysis, DNA
- Sheep