Article
Inherited somatic mosaicism caused by an intracisternal A particle insertion in the mouse tyrosinase gene.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 1997
Wu M, Rinchik E M, Wilkinson E, Johnson D K
Abstract excerpt
A recessive, fully penetrant mutation (c(m1OR)) at the mouse albino locus that results in coat-color mottling has been characterized at the molecular level. Restriction mapping and DNA sequencing analyses provide evidence that mutants carry a 5.4-kb intracisternal A particle (IAP) element inserti...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- Gene Expression Regulation, Enzymologic
- Genes
- Genes, Intracisternal A-Particle
- Hair Color
- Melanocytes
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Monophenol Monooxygenase
- Mosaicism
- Mutation
- Polymorphism, Restriction Fragment Length
- Promoter Regions, Genetic
- RNA, Messenger
- Sequence Analysis, DNA