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Article

Inherited somatic mosaicism caused by an intracisternal A particle insertion in the mouse tyrosinase gene.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 1997

Wu M, Rinchik E M, Wilkinson E, Johnson D K

Abstract excerpt

A recessive, fully penetrant mutation (c(m1OR)) at the mouse albino locus that results in coat-color mottling has been characterized at the molecular level. Restriction mapping and DNA sequencing analyses provide evidence that mutants carry a 5.4-kb intracisternal A particle (IAP) element insertion upstream of the tyrosinase (Tyr) promoter. Northern blot analysis and reverse transcription-PCR results show that...

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Identifiers

PMID: 9023352
DOI: 10.1073/pnas.94.3.890
PMCID: PMC19609

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