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Article

A murine model of hereditary hemorrhagic telangiectasia

15 Nov 1999

Abstract excerpt

Endoglin (CD105), an accessory protein of the TGF-beta receptor superfamily, is highly expressed on endothelial cells. Hereditary hemorrhagic telangiectasia type 1 (HHT1) is associated with mutations in the Endoglin gene, leading to haploinsufficiency. To generate a disease model and ascertain the role of endoglin in development, we generated mice lacking 1 or both copies of the gene. Endoglin null embryos die at...

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Identifiers

PMID: 10562296
DOI: 10.1172/jci8088

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Source receipt: pubmed, retrieved 7 Sept 2026.

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