Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice.

Human molecular genetics - 1 Jul 2003

Tang Yang, McKinnon Margaret L, Leong Li Ming, Rusholme Sarah A B, Wang Susana, Akhurst Rosemary J

Abstract excerpt

The transforming growth factor beta signaling family is a key player in genetic and multifactorial diseases, including hereditary hemorrhagic telangiectasia (HHT), cancer, atherosclerosis and immunomodulation. HHT types 1 and 2 are caused by loss of function mutations in ENG and ACVRL1; polymorph...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Platelets
Share to Cell Survival
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lod Score

Share to Mice, Transgenic

Share to Mitochondria

Share to Mothers

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 12812985
DOI: 10.1093/hmg/ddg164

Genes

ACVRL1
ENG
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12812985-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice.PMID 12812985Read ↗

Genetic variants of Adam17 differentially regulate TGFβ signaling to modify vascular pathology in mice and humans.Semantic proximity Read ↗

Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice.Semantic proximity Read ↗

Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis.Semantic proximity Read ↗

Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia.Semantic proximity Read ↗

TGFβ Signaling and Cardiovascular DiseasesSemantic proximity Read ↗

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.Semantic proximity Read ↗

Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations.Semantic proximity Read ↗

Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis.Semantic proximity Read ↗

Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways.Semantic proximity Read ↗

A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2.Semantic proximity Read ↗

Absence of cardiovascular manifestations in a haploinsufficient Tgfbr1 mouse model.Semantic proximity Read ↗

Signaling by members of the TGF-β family in vascular morphogenesis and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.