Article
Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster.
Environmental and molecular mutagenesis - 1 Jan 1997
Campesato V R, Graf U, Reguly M L, de Andrade H H
Abstract excerpt
Integerrimine (ITR), a pyrrolizidine alkaloid from Senecio brasiliensis, was tested for genotoxicity using the wing somatic mutation and recombination test (SMART) in Drosophila melanogaster. The compound was administered by chronic feeding (48 hours) of 3-day-old larvae. Two different crosses in...
Topics
- Animals
- Antineoplastic Agents, Phytogenic
- Chromosome Inversion
- Crosses, Genetic
- Drosophila melanogaster
- Female
- Heterozygote
- Larva
- Male
- Mitosis
- Mutagenicity Tests
- Mutation
- Plants, Toxic
- Pyrrolizidine Alkaloids
- Recombination, Genetic
- Senecio
- Sensitivity and Specificity
- Wings, Animal