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Article

Genotoxic evaluation of two oral antidiabetic agents in the Drosophila wing spot test.

Toxicology and industrial health - 1 May 2014

Gürbüzel Mehmet, Çapoğlu Ilyas, Kızılet Halit, Halıcı Zekai, Özçiçek Fatih, Demirtaş Levent

Abstract excerpt

In this study, two sulfonylureas--glimepiride and glipizide--commonly used in type 2 diabetes mellitus were investigated for genotoxicity in the Drosophila wing spot test. For this purpose, three-day-old transheterozygous larvae were treated with three mutagenic compounds, and the results obtained were compared with the control group. Mutational or recombinogenic changes were recorded in two recessive...

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PMID: 22914262
DOI: 10.1177/0748233712456091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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