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Article

Genotoxicity assessment of four novel quinazoline-derived trypanocidal agents in the Drosophila wing somatic mutation and recombination test.

Mutagenesis - 12 Sept 2020

Santos-Cruz Luis Felipe, Ramírez-Cruz Bertha Guadalupe, García-Salomé Miguel, Olvera-Romero Zaira Yuriria, Hernández-Luis Francisco, Hernández-Portilla Luis Barbo, Durán-Díaz Ángel, Dueñas-García Irma Elena, Castañeda-Partida Laura, Piedra-Ibarra Elías, Mendoza-Martínez César, Heres-Pulido María Eugenia

Abstract excerpt

Chagas disease, caused by the protozoan Trypanosoma cruzi, has increased in the world due to migration, travelling and climate change; at present, the principal problem is that common trypanocidal agents have resulted in toxic or inconvenient side effects. We tested for genotoxicity in the standard (ST) and high bioactivation (HB) crosses of Drosophila wing somatic mutation and recombination test, four novel...

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Identifiers

PMID: 31793639
DOI: 10.1093/mutage/gez042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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