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Article

Genotoxic effect of griseofulvin in somatic cells of Drosophila melanogaster.

Mutation research - 1 Jul 1995

Inoue H, Baba H, Awano K, Yoshikawa K

Abstract excerpt

Griseofulvin (GF), a carcinogenic spindle poison, was tested in two types of somatic-cell assays of Drosophila melanogaster, one of which detects the induction of DNA damage and the other mutation/mitotic recombination. In both assays, GF was fed to tester larvae and genetic endpoints examined after emergence. In the wing spot test, trans-heterozygous flies carrying mwh and flr3 wing-hair mutations produced both...

Topics

Animals
Crossing Over, Genetic
DNA Damage
DNA Repair
DNA Replication
Dose-Response Relationship, Drug
Drosophila melanogaster
Female
Fertility
Genes, Insect
Griseofulvin
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Larva

Male

Mutagenicity Tests

Mutagens

Mutation

Source

Identifiers

PMID: 7623877
DOI: 10.1016/0165-1218(95)90018-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7623877-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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