Article
Frequencies of hprt(-) mutations and bcl-2 translocations in circulating human lymphocytes are correlated with United Kingdom sunlight records.
Mutagenesis - 1 Nov 1999
Bentham G, Wolfreys A M, Liu Y, Cortopassi G, Green M H, Arlett C F, Cole J
Abstract excerpt
Between 1983 and 1995 we have monitored human populations for evidence of exposure to environmental mutagens, taking blood samples to measure hprt(-) mutant frequency in T cells and more recently bcl-2 t(14:18) translocation frequency in B cells. We have now analysed data from 785 assays on 448 blood samples from 308 normal subjects and find that there is a highly significant statistical correlation between...
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