Article
Degeneration of human oncogenes and mitochondrial genes occurs in cells that exhibit age-related pathology.
Experimental gerontology - 1 Jan 2000
Cortopassi G, Liu Y, Hutchin T
Abstract excerpt
The development of a new class of assays to determine in vivo mutation frequencies has provided new perspectives on the timing, location, and distribution of somatic mutagenesis in mitochondrial genes and in oncogenes of the aging human body. This descriptive information has led to the inference of new models for age-related pathophysiology and oncogenesis. Mutations of mitochondrial genes rise rapidly with age...
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