Article
"Loop" domain is necessary for taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting taxol-induced cytosolic accumulation of cytochrome c and apoptosis.
Cancer research - 1 Aug 1998
Fang G, Chang B S, Kim C N, Perkins C, Thompson C B, Bhalla K N
Abstract excerpt
Taxol, 1-beta-D-arabinofuranosylcytosine (ara-C), and etoposide induce apoptosis in HL-60 cells that is blocked by overexpression of Bcl-2 or Bcl-xL.A 60-amino acid "loop" domain of Bcl-2 and Bcl-xL that contains phosphorylation sites is known to negatively regulate their antiapoptotic function....
Topics
- Antimetabolites, Antineoplastic
- Antineoplastic Agents, Phytogenic
- Apoptosis
- Apoptotic Protease-Activating Factor 1
- Binding Sites
- Blotting, Western
- Cytarabine
- Cytochrome c Group
- Cytosol
- DNA, Neoplasm
- Etoposide