Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).

Molecular and cellular biology - 1 May 1990

Collins S J, Robertson K A, Mueller L

Abstract excerpt

Retinoic acid (RA) induces terminal granulocytic differentiation of the HL-60 promyelocytic leukemia cell line as well as certain other human myeloid leukemias. Specific RA receptors that are members of the steroid-thyroid hormone superfamily of nuclear transcription factors have recently been identified. We developed an HL-60 subclone that was relatively resistant to RA-induced differentiation. Specific nuclear...

Topics

CD18 Antigens
Carrier Proteins
Cell Differentiation
Cell Division
Gene Expression Regulation
Granulocytes
Humans
In Vitro Techniques
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-myc

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Leukocyte-Adhesion

Receptors, Retinoic Acid

Transfection

Tretinoin

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 1970118
DOI: 10.1128/mcb.10.5.2154-2163.1990
PMCID: PMC360563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1970118-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).PMID 1970118Read ↗

Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activitySemantic proximity Read ↗

Activation of retinoid receptors RAR alpha and RXR alpha induces differentiation and apoptosis, respectively, in HL-60 cells.Semantic proximity Read ↗

Mutation in the ligand-binding domain of the retinoic acid receptor alpha in HL-60 leukemic cells resistant to retinoic acid and with increased sensitivity to vitamin D3 analogs.Semantic proximity Read ↗

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemiaSemantic proximity Read ↗

Retinoic acid receptors, hematopoiesis and leukemogenesisSemantic proximity Read ↗

Revisiting the differentiation paradigm in acute promyelocytic leukemiaSemantic proximity Read ↗

Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.Semantic proximity Read ↗

Retinoic acid-induced growth arrest and differentiation: retinoic acid up-regulates CD32 (Fc gammaRII) expression, the ectopic expression of which retards the cell cycle.Semantic proximity Read ↗

A Retinoid-Resistant Acute Promyelocytic Leukemia Subclone Expresses a Dominant Negative PML-RARα MutationSemantic proximity Read ↗

Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.Semantic proximity Read ↗

Telomerase inhibition by retinoids precedes cytodifferentiation of leukemia cells and may contribute to terminal differentiation.Semantic proximity Read ↗

Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.