Article
Functional significance of induction of differentiation in human myeloid leukaemic blasts by 1,25-dihydroxyvitamin D3 and GM-CSF.
Leukemia research - 1 Jan 1992
Kelsey S M, Makin H L, Newland A C
Abstract excerpt
We studied the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and granulocyte-macrophage colony stimulating factor (GM-CSF) on monocytic differentiation of the U937 leukaemic cell line and blasts from patients with AML. 1,25(OH)2D3 and GM-CSF synergistically increased functional and phenotypic aspects of differentiation in the U937 cell line. In addition, the effective concentration of 1,25(OH)2D3 was reduced...
Topics
- Acute Disease
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Calcitriol
- Cell Differentiation
- Cell Division
- Dose-Response Relationship, Drug
- Drug Synergism
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans