Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response.

doi:10.1016/s1383-5718(99)00167-9

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Article

Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response.

Mutation research - 3 Jan 2000

Autrup H

Abstract excerpt

Biotransformation plays an important role in the carcinogenic activity and organ specificity of environmental carcinogens. Large interindividual variation in the biotransformation has been reported, and genetic polymorphisms in some xenobiotica metabolizing enzymes can in part explain some of these differences. The concentration of the ultimate carcinogen, that will react with DNA, is determined by the rate of...

Topics

Arylamine N-Acetyltransferase
Biotransformation
Carcinogens
Cytochrome P-450 Enzyme System
Enzymes
Genetic Predisposition to Disease
Glutathione Transferase
Humans
Neoplasms
Polymorphism, Genetic
Xenobiotics

Source

Open in PubMed

Identifiers

PMID: 10633178
DOI: 10.1016/s1383-5718(99)00167-9

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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