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Mutations affecting chromatid separation in Drosophila: the fizzy metaphase arrest persists in pimples fizzy and fizzy three rows double mutants.

Experimental cell research - 10 Jan 1997

Philp A V, Glover D M

Abstract excerpt

Mutations in the Drosophila genes three rows (thr), fizzy (fzy), and pimples (pim) block chromosome segregation in mitosis. fzy mutations also block cyclin degradation and affected cells become permanently arrested in metaphase. Mutations in pim and thr prevent chromatid separation but proteolysi...

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Mutation
Phenotype
Drosophila
Genes, Insect
Mitosis
Cyclins

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PMID: 9013712
DOI: 10.1006/excr.1996.3396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9013712-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Mutations affecting chromatid separation in Drosophila: the fizzy metaphase arrest persists in pimples fizzy and fizzy three rows double mutants.PMID 9013712Read ↗

Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition.Semantic proximity Read ↗

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.Semantic proximity Read ↗

Mitotic sister-chromatid separation: what Drosophila mutants can tell us.Semantic proximity Read ↗

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Mutations in the Drosophila melanogaster gene three rows permit aspects of mitosis to continue in the absence of chromatid segregation.Semantic proximity Read ↗

Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos.Semantic proximity Read ↗

The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.Semantic proximity Read ↗

Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegans.Semantic proximity Read ↗

The three rows gene of Drosophila melanogaster encodes a novel protein that is required for chromosome disjunction during mitosis.Semantic proximity Read ↗

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