Mutations affecting chromatid separation in Drosophila: the fizzy metaphase arrest persists in pimples fizzy and fizzy three rows double mutants.

Abstract excerpt

Mutations in the Drosophila genes three rows (thr), fizzy (fzy), and pimples (pim) block chromosome segregation in mitosis. fzy mutations also block cyclin degradation and affected cells become permanently arrested in metaphase. Mutations in pim and thr prevent chromatid separation but proteolysis of mitotic cyclins occurs normally and cells leave mitosis. Since it has been shown that active cdc2 is required to...

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