Article
Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice.
The Journal of general virology - 1 Jan 1997
Holzmann H, Stiasny K, Ecker M, Kunz C, Heinz F X
Abstract excerpt
Escape mutants of tick-borne encephalitis (TBE) virus were selected using neutralizing monoclonal antibodies (MAbs) that react with three different and previously unrecognized epitopes in the envelope protein E of TBE virus. Two of these variants (V-IC3 and V-IE3) exhibited a significantly reduce...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Base Sequence
- Chick Embryo
- Encephalitis Viruses, Tick-Borne
- Enzyme-Linked Immunosorbent Assay
- Genetic Variation
- Mice
- Molecular Sequence Data
- Nervous System
- Neutralization Tests
- Phenotype
- Point Mutation
- RNA, Viral
- Temperature
- Viral Envelope Proteins
- Viral Plaque Assay