Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice.

The Journal of general virology - 1 Jan 1997

Holzmann H, Stiasny K, Ecker M, Kunz C, Heinz F X

Abstract excerpt

Escape mutants of tick-borne encephalitis (TBE) virus were selected using neutralizing monoclonal antibodies (MAbs) that react with three different and previously unrecognized epitopes in the envelope protein E of TBE virus. Two of these variants (V-IC3 and V-IE3) exhibited a significantly reduced reactivity with their selecting MAbs, as determined by ELISA, whereas with one variant (V-IO3), reactivity was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Phenotype

Share to Point Mutation

Share to Temperature

Source

Identifiers

PMID: 9010282
DOI: 10.1099/0022-1317-78-1-31

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice.PMID 9010282Read ↗

A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model.Semantic proximity Read ↗

The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protectionSemantic proximity Read ↗

The Envelope Protein of Tick-Borne Encephalitis Virus Influence Neuron Entry, Pathogenicity and Vaccine ProtectionSemantic proximity Read ↗

Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in miceSemantic proximity Read ↗

Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus.Semantic proximity Read ↗

Phylogenetic and virulence analysis of tick-borne encephalitis virus field isolates from Switzerland.Semantic proximity Read ↗

Nucleotide changes responsible for loss of neuroinvasiveness in Japanese encephalitis virus neutralization-resistant mutants.Semantic proximity Read ↗

A BHK-21 cell culture-adapted tick-borne encephalitis virus mutant is attenuated for neuroinvasiveness.Semantic proximity Read ↗

Murray valley encephalitis virus envelope protein antigenic variants with altered hemagglutination properties and reduced neuroinvasiveness in mice.Semantic proximity Read ↗

West Nile 25A virus infection of B-cell-deficient ((micro)MT) mice: characterization of neuroinvasiveness and pseudoreversion of the viral envelope protein.Semantic proximity Read ↗

A molecularly cloned, live-attenuated japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the ij Hairpin of the Viral E glycoprotein determines neurovirulence in mice.Semantic proximity Read ↗

Molecular characterization of the monoclonal antibodies composing ZMAb: a protective cocktail against Ebola virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.