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Article

Expression of the cystic fibrosis phenotype in a renal amphibian epithelial cell line.

The Journal of biological chemistry - 3 Jan 1997

Ling B N, Zuckerman J B, Lin C, Harte B J, McNulty K A, Smith P R, Gomez L M, Worrell R T, Eaton D C, Kleyman T R

Abstract excerpt

Mutations in a Cl- channel (cystic fibrosis transmembrane conductance regulator or CFTR) are responsible for the cystic fibrosis (CF) phenotype. Increased Na+ transport rates are observed in CF airway epithelium, and recent studies suggest that this is due to an increase in Na+ channel open probability (Po). The Xenopus renal epithelial cell line, A6, expresses both cAMP-activated 8-picosiemen (pS) Cl- channels...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8995302
DOI: 10.1074/jbc.272.1.594

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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