Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Xist-deficient mice are defective in dosage compensation but not spermatogenesis.

Genes & development - 15 Jan 1997

Marahrens Y, Panning B, Dausman J, Strauss W, Jaenisch R

Abstract excerpt

The X-linked Xist gene encodes a large untranslated RNA that has been implicated in mammalian dosage compensation and in spermatogenesis. To investigate the function of the Xist gene product, we have generated male and female mice that carry a deletion in the structural gene but maintain a functional Xist promoter. Mutant males were healthy and fertile. Females that inherited the mutation from their mothers were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Crosses, Genetic
Share to Embryonic and Fetal Development

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Mice, Inbred BALB C

Share to Phenotype

Share to Transcription Factors

Source

Identifiers

PMID: 9009199
DOI: 10.1101/gad.11.2.156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Xist-deficient mice are defective in dosage compensation but not spermatogenesis.PMID 9009199Read ↗

Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation.Semantic proximity Read ↗

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.Semantic proximity Read ↗

Defects in dosage compensation impact global gene regulation in the mouse trophoblast.Semantic proximity Read ↗

Loss of methylation activates Xist in somatic but not in embryonic cells.Semantic proximity Read ↗

Expression of the X–inactivation–associated gene XIST during spermatogenesisSemantic proximity Read ↗

Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line.Semantic proximity Read ↗

Advances in understanding chromosome silencing by the long non-coding RNA Xist.Semantic proximity Read ↗

De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation.Semantic proximity Read ↗

Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse.Semantic proximity Read ↗

Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation.Semantic proximity Read ↗

Deficient transcription of XIST from tiny ring X chromosomes in females with severe phenotypes.Semantic proximity Read ↗

Tsix-deficient X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.