Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recombinant staphylokinase variants with altered immunoreactivity. IV: Identification of variants with reduced antibody induction but intact potency.

Circulation - 21 Jan 1997

Collen D, Stockx L, Lacroix H, Suy R, Vanderschueren S

Abstract excerpt

BACKGROUND: The thrombolytic potency and antibody induction of selected variants of recombinant staphylokinase (SakSTAR), including SakSTAR(K74) with Lys74, SakSTAR(E75) with Glu75-, SakSTAR(EER) with Glu38, Glu75, and Arg77, and SakSTAR(K74ER) with Lys74, Glu75, and Arg77 replaced by Ala, were studied. METHODS AND RESULTS: In rabbits, SakSTAR(74) and SakSTAR(EER) elicited significantly less circulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Antibodies
Share to Antibody Formation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Immunization

Share to Metalloendopeptidases

Share to Rabbits

Share to Recombinant Proteins

Source

Identifiers

PMID: 9008465
DOI: 10.1161/01.cir.95.2.463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recombinant staphylokinase variants with altered immunoreactivity. IV: Identification of variants with reduced antibody induction but intact potency.PMID 9008465Read ↗

Recombinant staphylokinase variants with altered immunoreactivity. III: Species variability of antibody binding patterns.Semantic proximity Read ↗

Recombinant Staphylokinase Variants With Altered ImmunoreactivitySemantic proximity Read ↗

Construction of a novel Staphylokinase (SAK) mutant with low immunogenicity and its evaluation in rhesus monkey.Semantic proximity Read ↗

Biochemical and Immunological Properties of Engineered Low-Immunogenic Staphylokinases for Next-Generation Thrombolytic TherapySemantic proximity Read ↗

Construction and characterization of novel staphylokinase variants with antiplatelet aggregation activity and reduced immunogenecity.Semantic proximity Read ↗

Novel recombinant thrombolytic and antithrombotic staphylokinase variants with an RGD motif at their N-termini.Semantic proximity Read ↗

Functional properties of a novel mutant of staphylokinase with platelet-targeted fibrinolysis and antiplatelet aggregation activities.Semantic proximity Read ↗

In vitro characterization of a multifunctional staphylokinase variant with reduced reocclusion, produced from salt inducible E. coli GJ1158.Semantic proximity Read ↗

[Expression, purification and characterization of a novel staphylokinase with anti-platelet aggregation activity].Semantic proximity Read ↗

Mechanistic studies on Zymogen-Activator and Adhesion Proteins (ZAAPs) as thrombolytic drugs and bacterial virulence factorsSemantic proximity Read ↗

Investigating the Conformational Flexibility of Staphylokinase Across Multiple Time ScalesSemantic proximity Read ↗

Refolding of a staphylokinase variant y1-Sak by reverse dilution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.