Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Expression, purification and characterization of a novel staphylokinase with anti-platelet aggregation activity].

Wei sheng wu xue bao = Acta microbiologica Sinica - 1 Sept 2008

Jingfang Di, Jintian He, Ruiguang Xu, Xi Chen, Baohua Zhao

Abstract excerpt

OBJECTIVE: To investigate construction and expression of novel staphylokinase (SAK) mutants with Arg-Gly-Asp (RGD) motif at its N-terminus, and to develop a novel thrombolytic agent with fibrinolytic activity and anti-platelet activity. METHODS: The fragments of SAK mutants were inserted into expression plasmid pBV220 and recombinant vectors were transformed into E. coli BL21, The SAK mutants could be expressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Metalloendopeptidases

Share to Mutation

Share to Platelet Aggregation

Share to Platelet Aggregation Inhibitors

Share to Recombinant Proteins

Source

Identifiers

PMID: 19062642

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Expression, purification and characterization of a novel staphylokinase with anti-platelet aggregation activity].PMID 19062642Read ↗

Novel recombinant thrombolytic and antithrombotic staphylokinase variants with an RGD motif at their N-termini.Semantic proximity Read ↗

Functional properties of a novel mutant of staphylokinase with platelet-targeted fibrinolysis and antiplatelet aggregation activities.Semantic proximity Read ↗

Construction and characterization of novel staphylokinase variants with antiplatelet aggregation activity and reduced immunogenecity.Semantic proximity Read ↗

In vitro characterization of a multifunctional staphylokinase variant with reduced reocclusion, produced from salt inducible E. coli GJ1158.Semantic proximity Read ↗

Construction of a novel Staphylokinase (SAK) mutant with low immunogenicity and its evaluation in rhesus monkey.Semantic proximity Read ↗

Engineering and production of streptokinase in a Bacillus subtilis expression-secretion system.Semantic proximity Read ↗

Refolding of a staphylokinase variant y1-Sak by reverse dilution.Semantic proximity Read ↗

[Structural study of staphylokinase related with the expression of activity].Semantic proximity Read ↗

Mechanistic studies on Zymogen-Activator and Adhesion Proteins (ZAAPs) as thrombolytic drugs and bacterial virulence factorsSemantic proximity Read ↗

Production of recombinant streptokinase from Streptococcus pyogenes isolate and its potential for thrombolytic therapySemantic proximity Read ↗

Staphylokinase as a Plasminogen Activator Component in Recombinant Fusion ProteinsSemantic proximity Read ↗

Over expression of recombinant Staphylokinase and reduction of inclusion bodies using IPTG as inducer in E. coli BL21 DE3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.