Mutations conferring resistance to zidovudine diminish the antiviral effect of stavudine plus didanosine.

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Article

Mutations conferring resistance to zidovudine diminish the antiviral effect of stavudine plus didanosine.

Journal of medical virology - 1 Dec 1999

Izopet J, Bicart-See A, Pasquier C, Sandres K, Bonnet E, Marchou B, Puel J, Massip P

Abstract excerpt

This study evaluated the influence of zidovudine (ZDV) resistance mutations on the antiviral effect of the combination of stavudine (D4T) plus didanosine (ddI) in patients treated previously with ZDV plus zalcitabine (ddC). Twenty patients who had been treated with ZDV plus ddC for a median duration of 11 months (range, 7-42 months) were switched to D4T (40 mg twice a day [BID]) + ddI (200 mg BID) in an open...

Topics

Adult
Anti-HIV Agents
CD4 Lymphocyte Count
Didanosine
Drug Resistance
Drug Therapy, Combination
Female
HIV Infections
HIV Reverse Transcriptase
HIV-1
Humans
Male
Mutation
Pilot Projects
RNA, Viral
Reverse Transcriptase Inhibitors
Stavudine
Zidovudine

Source

Open in PubMed

Identifiers

PMID: 10534734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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