Article
A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary.
Development (Cambridge, England) - 1 Aug 1998
Lun K, Brand M
Abstract excerpt
Generation of cell diversity in the vertebrate central nervous system starts during gastrulation stages in the ectodermal germ layer and involves specialized cell groups, such as the organizer located at the midbrain-hindbrain boundary (MHB). Mutations in the zebrafish no isthmus (noi) gene alter...
Topics
- Alleles
- Animals
- Brain
- Conserved Sequence
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Genetic Markers
- In Situ Hybridization
- Mutation
- Nuclear Proteins
- PAX2 Transcription Factor
- PAX5 Transcription Factor
- PAX8 Transcription Factor
- Paired Box Transcription Factors
- RNA Splicing
- Signal Transduction
- Trans-Activators
- Transcription Factors