Article
Genetic interactions in zebrafish midline development.
Developmental biology - 15 Jul 1997
Halpern M E, Hatta K, Amacher S L, Talbot W S, Yan Y L, Thisse B, Thisse C, Postlethwait J H, Kimmel C B
Abstract excerpt
Mutational analyses have shown that the genes no tail (ntl, Brachyury homolog), floating head (flh, a Not homeobox gene), and cyclops (cyc) play direct and essential roles in the development of midline structures in the zebrafish. In both ntl and flh mutants a notochord does not develop, and in cyc mutants the floor plate is nearly entirely missing. We made double mutants to learn how these genes might interact....
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