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Article

The sensitivity of different analytical methods to detect disease susceptibility genes in rheumatoid arthritis sibling pair families.

The Journal of rheumatology - 1 Jan 1997

Marlow A, John S, Hajeer A, Ollier W E, Silman A J, Worthington J

Abstract excerpt

Our aim was to compare the sensitivity of 4 analytical methods to detect linkage to a known disease susceptibility locus, HLA-DRB1, in 100 rheumatoid arthritis sibling pair families with incomplete parental genotype information. Genotypes for the HLA-DRB1 and HLA-A loci were analyzed using (1) identity-by-descent (IBD), considering inheritance of maternal and paternal alleles separately; (2) maximum likelihood...

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PMID: 9002041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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