Article
Investigation of candidate disease susceptibility genes in rheumatoid arthritis: principles and strategies.
The Journal of rheumatology - 1 Jan 1997
John S, Hajeer A, Marlow A, Myerscough A, Silman A J, Ollier W E, Worthington J
Abstract excerpt
It has been estimated that a number of non-HLA susceptibility loci exist in rheumatoid arthritis (RA), each making relatively small contributions (lambda s < 2). Previous approaches for whole genome screening are unlikely to be sufficiently sensitive to detect such loci. As the pathology of RA already indicates several molecules that may be of potential importance in disease susceptibility, we propose an...
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