Investigation of candidate disease susceptibility genes in rheumatoid arthritis: principles and strategies.

Article

Investigation of candidate disease susceptibility genes in rheumatoid arthritis: principles and strategies.

The Journal of rheumatology - 1 Jan 1997

John S, Hajeer A, Marlow A, Myerscough A, Silman A J, Ollier W E, Worthington J

Abstract excerpt

It has been estimated that a number of non-HLA susceptibility loci exist in rheumatoid arthritis (RA), each making relatively small contributions (lambda s < 2). Previous approaches for whole genome screening are unlikely to be sufficiently sensitive to detect such loci. As the pathology of RA al...

Topics

Arthritis, Rheumatoid
Female
Genetic Linkage
Genetic Predisposition to Disease
Humans
Male
Prevalence
Risk Factors

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