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Article

Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system.

Protein science : a publication of the Protein Society - 1 Jul 2009

Lawson Alexander J, Walker Elizabeth A, White Scott A, Dafforn Timothy R, Stewart Paul M, Ride Jonathan P

Abstract excerpt

11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) is a key enzyme in the conversion of cortisone to the functional glucocorticoid hormone cortisol. This activation has been implicated in several human disorders, notably the metabolic syndrome where 11 beta-HSD1 has been identified as a novel target for potential therapeutic drugs. Recent crystal structures have revealed the presence of a pronounced...

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PMID: 19507261
DOI: 10.1002/pro.150
PMCID: PMC2775222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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