Article
Role of conserved hydrophobic amino acids in androgen receptor AF-1 function.
Journal of molecular endocrinology - 1 Dec 2003
Betney R, McEwan I J
Abstract excerpt
The intracellular androgen receptor (AR) is a ligand-activated transcription factor. Upon binding the steroids testosterone or dihydrotestosterone, the activated receptor translocates to the nucleus, binds to specific DNA response elements and interacts with the transcription machinery in order to regulate gene transcription. In the present study, we have described a highly conserved region (amino acids 224-258)...
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