Article
Glucocorticoid receptor point mutation V571M facilitates coactivator and ligand binding by structural rearrangement and stabilization.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2005
Carlsson Peter, Koehler Konrad F, Nilsson Lennart
Abstract excerpt
Two-point mutations in the human glucocorticoid receptor have been studied by computer simulations to rationalize experimental data, where mutants comprising the V571M substitution improve both transcriptional activity and affinity for aldosterone despite large distances between the mutated residue and the coactivator-binding surface and ligand-binding pocket, respectively. Our molecular dynamics simulations show...
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