Second-site proviral enhancer alterations in lymphomas induced by enhancer mutants of SL3-3 murine leukemia virus: negative effect of nuclear factor 1 binding site.

Abstract excerpt

SL3-3 is a highly T-lymphomagenic murine retrovirus. Previously, mutation of binding sites in the U3 repeat region for the AML1 transcription factor family (also known as core binding factor [CBF], polyomavirus enhancer binding protein 2 [PEBP2], and SL3-3 enhancer factor 1 [SEF1]) were found to...

Topics

• Base Sequence
• Binding Sites
• Core Binding Factors
• DNA-Binding Proteins
• Enhancer Elements, Genetic
• Humans
• Leukemia Virus, Murine
• Lymphoma
• Molecular Sequence Data
• Mutation
• Neoplasm Proteins
• Transcription Factors