Article
An SL3-3 murine leukemia virus enhancer variant more pathogenic than the wild type obtained by assisted molecular evolution in vivo.
Journal of virology - 1 Dec 1997
Ethelberg S, Sørensen A B, Schmidt J, Luz A, Pedersen F S
Abstract excerpt
SL3-3 is a highly T-lymphomagenic murine retrovirus in which the transcriptional enhancer is a major oncogenic determinant. Here, we describe an SL3-3 enhancer variant that induced T-cell lymphomas in all inoculated mice with a shorter latency period than wild-type SL3-3. The enhancer repeat regi...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- DNA, Viral
- Enhancer Elements, Genetic
- Evolution, Molecular
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genetic Variation
- Leukemia Virus, Murine
- Lymphoma, T-Cell
- Mice
- Molecular Sequence Data
- Proviruses
- Receptors, Antigen, T-Cell, alpha-beta