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Article

Developmental role of GABAB(1) receptors in Drosophila.

Brain research. Developmental brain research - 8 Aug 2005

Dzitoyeva Svetlana, Gutnov Alan, Imbesi Marta, Dimitrijevic Nikola, Manev Hari

Abstract excerpt

Previously, an RNA interference (RNAi) knockdown of GABAB(1) subunit in adult Drosophila was used for behavioral studies. Here we report on developmental deficits caused by embryonic Drosophila GABAB(1) RNAi and drug antagonism. Injecting embryos with CGP54626 (a GABAB receptor antagonist) reduced hatching and caused lethality. Similar effects were produced by injecting embryos with GABAB(1) double-stranded RNA...

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Identifiers

PMID: 16054235
DOI: 10.1016/j.devbrainres.2005.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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