Article
PCR-mismatch analysis of p53 gene mutation in Hodgkin's disease.
The Journal of pathology - 1 Feb 1995
Xerri L, Parc P, Bouabdallah R, Camerlo J, Hassoun J
Abstract excerpt
Expression of the p53 protein can be detected by immunohistochemistry in Reed-Sternberg (RS) cells, the presumed neoplastic component of Hodgkin's disease (HD) lesions. At present, there is no clear molecular evidence that p53 positive immunostaining in HD correlates with the presence of mutations or other structural alterations of the p53 gene. To address this question, 49 cases of HD have been investigated for...
Topics
- Gene Expression
- Genes, p53
- Hodgkin Disease
- Humans
- Mutation
- Neoplasm Proteins
- Polymerase Chain Reaction
- Reed-Sternberg Cells
- Tumor Suppressor Protein p53