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Article

Abeta42, presenilins, and Alzheimer's disease.

Neurobiology of aging - 1 Jan 2000

Iwatsubo T

Abstract excerpt

The significance of amyloid beta protein, especially those ending at the 42nd residue (Abeta42), in the pathogenesis of familial Alzheimer's disease (FAD) linked to the mutations of presenilins, was examined by transfection studies using cultured cells and immunohistochemical analysis of autopsied brains. The levels of Abeta42 secreted from cells transfected with mutant presenilins linked to FAD, as well as the...

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PMID: 9562460
DOI: 10.1016/s0197-4580(98)00027-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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