Article
Abeta42, presenilins, and Alzheimer's disease.
Neurobiology of aging - 1 Jan 2000
Iwatsubo T
Abstract excerpt
The significance of amyloid beta protein, especially those ending at the 42nd residue (Abeta42), in the pathogenesis of familial Alzheimer's disease (FAD) linked to the mutations of presenilins, was examined by transfection studies using cultured cells and immunohistochemical analysis of autopsie...
Topics
- Alzheimer Disease
- Amyloid beta-Peptides
- Brain
- Cells, Cultured
- Humans
- Membrane Proteins
- Mutation
- Peptide Fragments
- Plaque, Amyloid
- Presenilin-1
- Presenilin-2
- Tissue Fixation
- Transfection