Article
Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations.
Journal of Alzheimer's disease : JAD - 1 Feb 2004
Vitali Antonella, Piccini Alessandra, Borghi Roberta, Fornaro Pantaleo, Siedlak Sandra L, Smith Mark A, Gambetti Pierluigi, Ghetti Bernardino, Tabaton Massimo
Abstract excerpt
The relationship between senile plaques and neurofibrillary tangles, the main pathologic lesions of Alzheimer's disease, is not completely understood. We addressed this issue examining the type and amount of amyloid beta-protein (Abeta) associated with the soluble and insoluble tissue fractions in the frontal cortex of 8 cases with frontotemporal dementia with parkinsonism caused by mutations of the Tau gene...
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