Article
Aldehyde dehydrogenase and acetaldehyde metabolism.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement - 1 Jan 1994
Weiner H, Wang X
Abstract excerpt
Ingested ethanol is first oxidized to acetaldehyde, primarily in the liver, then further oxidized to acetate. The oxidation of acetaldehyde is catalyzed by an NAD-dependent aldehyde dehydrogenase located in the liver mitochondrial matrix space. To date only one variant form of aldehyde dehydrogenase has been identified. Many Oriental people have an inactive mitochondrial form which possesses a lysine residue at...
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