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Alcohol dehydrogenase and aldehyde dehydrogenase in malignant neoplasms

17 Feb 2016

Abstract excerpt

According to International Agency for Research on Cancer, ethanol and acetaldehyde belong to group 1 of human carcinogens. The accurate mechanism by which alcohol consumption enhances carcinogenesis is still unexplained. Alcohol is oxidized primarily by alcohol dehydrogenase (ADH) to acetaldehyde, a substance capable of initiating carcinogenesis by forming adducts with proteins and DNA and causing mutations....

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PMID: 26886278
DOI: 10.1007/s10238-016-0408-3

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