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Article

Sustained signaling by phospholipase C-gamma mediates nerve growth factor-triggered gene expression.

Molecular and cellular biology - 1 Apr 2001

Choi D Y, Toledo-Aral J J, Segal R, Halegoua S

Abstract excerpt

In contrast to conventional signaling by growth factors that requires their continual presence, a 1-min pulse of nerve growth factor (NGF) is sufficient to induce electrical excitability in PC12 cells due to induction of the peripheral nerve type 1 (PN1) sodium channel gene. We have investigated the mechanism for this triggered signaling pathway by NGF in PC12 cells. Mutation of TrkA at key autophosphorylation...

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Source

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Identifiers

PMID: 11283249
DOI: 10.1128/MCB.21.8.2695-2705.2001
PMCID: PMC86900

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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