Article
Sustained signaling by phospholipase C-gamma mediates nerve growth factor-triggered gene expression.
Molecular and cellular biology - 1 Apr 2001
Choi D Y, Toledo-Aral J J, Segal R, Halegoua S
Abstract excerpt
In contrast to conventional signaling by growth factors that requires their continual presence, a 1-min pulse of nerve growth factor (NGF) is sufficient to induce electrical excitability in PC12 cells due to induction of the peripheral nerve type 1 (PN1) sodium channel gene. We have investigated...
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