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Article

Molecular characterization of replication-competent variants of adenovirus vectors and genome modifications to prevent their occurrence.

Journal of virology - 1 Dec 1996

Hehir K M, Armentano D, Cardoza L M, Choquette T L, Berthelette P B, White G A, Couture L A, Everton M B, Keegan J, Martin J M, Pratt D A, Smith M P, Smith A E, Wadsworth S C

Abstract excerpt

Adenovirus (Ad) vectors for gene therapy are made replication defective by deletion of E1 region genes. For isolation, propagation, and large-scale production of such vectors, E1 functions are supplied in trans from a stable cell line. Virtually all Ad vectors used for clinical studies are produced in the 293 cell, a human embryonic kidney cell line expressing E1 functions from an integrated segment of the left...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8970968
DOI: 10.1128/JVI.70.12.8459-8467.1996
PMCID: PMC190936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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