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Article

Altered recognition mutants of the response regulator PhoB: a new genetic strategy for studying protein-protein interactions.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 1996

Haldimann A, Prahalad M K, Fisher S L, Kim S K, Walsh C T, Wanner B L

Abstract excerpt

Two-component regulatory systems require highly specific interactions between histidine kinase (transmitter) and response regulator (receiver) proteins. We have developed a novel genetic strategy that is based on tightly regulated synthesis of a given protein to identify domains and residues of a...

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Identifiers

PMID: 8962056
DOI: 10.1073/pnas.93.25.14361
PMCID: PMC26137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8962056-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Altered recognition mutants of the response regulator PhoB: a new genetic strategy for studying protein-protein interactions.PMID 8962056Read ↗

The X-ray crystal structures of two constitutively active mutants of the Escherichia coli PhoB receiver domain give insights into activation.Semantic proximity Read ↗

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Phosphate sensing by PhoPR regulates the cytotoxicity of <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Phenotype microarray analysis of Escherichia coli K-12 mutants with deletions of all two-component systems.Semantic proximity Read ↗

Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ.Semantic proximity Read ↗

Phosphorylation of a conserved intrinsically disordered region is necessary for activation of a bacterial Hanks-type Ser/Thr kinase signaling pathwaySemantic proximity Read ↗

Role of Position K+4 in the Phosphorylation and Dephosphorylation Reaction Kinetics of the CheY Response Regulator.Semantic proximity Read ↗

Atypical Role for PhoU in Mutagenic Break Repair under Stress in Escherichia coli.Semantic proximity Read ↗

Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism.Semantic proximity Read ↗

Acetyl phosphate-dependent activation of a mutant PhoP response regulator that functions independently of its cognate sensor kinase.Semantic proximity Read ↗

The ciaR/ciaH regulatory network of Streptococcus pneumoniae.Semantic proximity Read ↗

Action of receiver and activator modules of UhpA in transcriptional control of the Escherichia coli sugar phosphate transport system.Semantic proximity Read ↗

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