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Article

Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ.

Proceedings of the National Academy of Sciences of the United States of America - 4 May 2010

Goldberg Shalom D, Clinthorne Graham D, Goulian Mark, DeGrado William F

Abstract excerpt

PhoQ is the transmembrane sensor histidine kinase of the bacterial phoPQ two-component system, which detects and responds to divalent cations and to antimicrobial peptides, and can trigger virulence. Despite their ubiquitous importance in bacterial signaling, the structure and mechanism of the sensor kinases are not fully understood. In particular, the mechanism by which the signal is propagated through the...

Topics

Bacterial Proteins
Cell Membrane
Escherichia coli
Models, Molecular
Mutation
Protein Structure, Tertiary
Signal Transduction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20404199
DOI: 10.1073/pnas.1003166107
PMCID: PMC2889538

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Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ.PMID 20404199Read ↗

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