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Article

Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism.

Protein science : a publication of the Protein Society - 1 Nov 2002

Da Re Sandra, Tolstykh Tatiana, Wolanin Peter M, Stock Jeffry B

Abstract excerpt

Response regulator proteins of two-component systems are usually activated by phosphorylation. The phosphorylated response regulator protein CheY-P mediates the chemotaxis response in Escherichia coli. We performed random mutagenesis and selected CheY mutants that are constitutively active in the absence of phosphorylation. Although a single amino acid substitution can lead to constitutive activation, no single...

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Identifiers

PMID: 12381847
DOI: 10.1110/ps.0220402
PMCID: PMC2373717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism.PMID 12381847Read ↗

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