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Article

Atypical Role for PhoU in Mutagenic Break Repair under Stress in Escherichia coli.

PloS one - 1 Jan 2015

Gibson Janet L, Lombardo Mary-Jane, Aponyi Ildiko, Vera Cruz Diana, Ray Mellanie P, Rosenberg Susan M

Abstract excerpt

Mechanisms of mutagenesis activated by stress responses drive pathogen/host adaptation, antibiotic and anti-fungal-drug resistance, and perhaps much of evolution generally. In Escherichia coli, repair of double-strand breaks (DSBs) by homologous recombination is high fidelity in unstressed cells, but switches to a mutagenic mode using error-prone DNA polymerases when the both the SOS and general (σS) stress...

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Identifiers

PMID: 25961709
DOI: 10.1371/journal.pone.0123315
PMCID: PMC4427277

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Source receipt: pubmed, retrieved 7 Sept 2026.

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