Article
Acetyl phosphate-dependent activation of a mutant PhoP response regulator that functions independently of its cognate sensor kinase.
Journal of molecular biology - 7 Jul 2000
Chamnongpol S, Groisman E A
Abstract excerpt
The two-component system is a signal communication network generally consisting of a sensor kinase that receives inputs from the environment and modifies the phosphorylated state of a response regulator that executes an adaptive behavior. PhoP is a response regulator that controls virulence gene expression in Salmonella enterica. Transcription of PhoP-regulated genes is modulated by the Mg(2+) levels detected by...
Topics
- Alleles
- Amino Acid Substitution
- Bacterial Proteins
- Environment
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Genes, Regulator
- Magnesium
- Membrane Proteins
- Methyl-Accepting Chemotaxis Proteins
- Models, Molecular
- Mutation
- Operon
- Organophosphates