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Article

Concentration and pH dependence of skeletal muscle chloride channel ClC-1.

The Journal of physiology - 1 Dec 1996

Rychkov G Y, Pusch M, Astill D S, Roberts M L, Jentsch T J, Bretag A H

Abstract excerpt

1. The influence of Cl- concentration and pH on gating of the skeletal muscle Cl- channel, ClC-1, has been assessed using the voltage-clamp technique and the Sf-9 insect cell and Xenopus oocyte expression systems. 2. Hyperpolarization induces deactivating inward currents comprising a steady-state component and two exponentially decaying components, of which the faster is weakly voltage dependent and the slower...

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Identifiers

PMID: 8961185
DOI: 10.1113/jphysiol.1996.sp021778
PMCID: PMC1160994

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