Article
Concentration and pH dependence of skeletal muscle chloride channel ClC-1.
The Journal of physiology - 1 Dec 1996
Rychkov G Y, Pusch M, Astill D S, Roberts M L, Jentsch T J, Bretag A H
Abstract excerpt
1. The influence of Cl- concentration and pH on gating of the skeletal muscle Cl- channel, ClC-1, has been assessed using the voltage-clamp technique and the Sf-9 insect cell and Xenopus oocyte expression systems. 2. Hyperpolarization induces deactivating inward currents comprising a steady-state...
Topics
- Animals
- Benzoates
- Benzoic Acid
- Chloride Channels
- Chlorides
- Dose-Response Relationship, Drug
- Female
- Food Preservatives
- Hydrogen-Ion Concentration
- Ion Channel Gating
- Kinetics
- Membrane Potentials
- Muscle, Skeletal
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Rats
- Xenopus