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Article

Differential acidic pH sensitivity of delta F508 CFTR Cl- channel activity in lipid bilayers.

The American journal of physiology - 1 Mar 1994

Sherry A M, Cuppoletti J, Malinowska D H

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is present in acidic intracellular vesicles. Human normal and delta F508 CFTR Cl- channel characteristics at pH 7.4 and pH 4.5 were determined by fusing Xenopus laevis oocyte plasma membranes containing the expressed channels to planar lipid bilayers. At pH 7.4, both channels exhibited linear current-voltage curves, a 10 +/- 0.3-pS conductance using 800...

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Source

Identifiers

PMID: 7513123
DOI: 10.1152/ajpcell.1994.266.3.C870

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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