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Article

Differential acidic pH sensitivity of delta F508 CFTR Cl- channel activity in lipid bilayers.

The American journal of physiology - 1 Mar 1994

Sherry A M, Cuppoletti J, Malinowska D H

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is present in acidic intracellular vesicles. Human normal and delta F508 CFTR Cl- channel characteristics at pH 7.4 and pH 4.5 were determined by fusing Xenopus laevis oocyte plasma membranes containing the expressed channels to planar lipid bilayers. At pH 7.4, both channels exhibited linear current-voltage curves, a 10 +/- 0.3-pS conductance using 800...

Topics

Acids
Animals
Chloride Channels
Cystic Fibrosis Transmembrane Conductance Regulator
Electrophysiology
Gene Deletion
Humans
Hydrogen-Ion Concentration
Lipid Bilayers
Membrane Proteins
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oocytes

Xenopus laevis

Source

Identifiers

PMID: 7513123
DOI: 10.1152/ajpcell.1994.266.3.C870

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7513123-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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