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Article

Expression of NF2 gene product merlin in arachnoid villi and meningiomas.

Noshuyo byori = Brain tumor pathology - 1 Nov 1996

Sakuda K, Kohda Y, Matsumoto T, Park C, Seto A, Tohma Y, Hasegawa M, Kida S, Nitta H, Yamashima T, Yamashita J

Abstract excerpt

Neurofibromatosis type 2 (NF2) gene encodes a novel 595 amino acid protein named merlin. Recently, Ruttledge et al demonstrated inactivation of NF2 gene in approximately 60% of sporadically occurring meningiomas. Merlin is thought to physiologically exist beneath the cell membrane, and to form a part of modulation in signal transduction, for example, information concerning contact inhibition. In NF2-related...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8958521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Expression of NF2 gene product merlin in arachnoid villi and meningiomas.PMID 8958521Read ↗

The Role of Merlin/NF2 Loss in Meningioma BiologySemantic proximity Read ↗

<i>NF2</i>: The wizardry of merlinSemantic proximity Read ↗

A neuronal function of the tumor suppressor protein merlin.Semantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth.Semantic proximity Read ↗

Neurofibromatosis 2: loss of merlin's protective spell.Semantic proximity Read ↗

Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cellsSemantic proximity Read ↗

Detection of cellular proteins that interact with the NF2 tumor suppressor gene product.Semantic proximity Read ↗

Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous systemSemantic proximity Read ↗

Shedding light on Merlin's wizardry.Semantic proximity Read ↗

The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeletonSemantic proximity Read ↗

The Neurofibromatosis 2 Tumor Suppressor Gene Product, Merlin, Regulates Human Meningioma Cell Growth by Signaling through YAPSemantic proximity Read ↗

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