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Article

Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth.

Neurobiology of disease - 1 Feb 2008

James Marianne F, Lelke Johanna M, Maccollin Mia, Plotkin Scott R, Stemmer-Rachamimov Anat O, Ramesh Vijaya, Gusella James F

Abstract excerpt

Meningiomas, common tumors arising from arachnoidal cells of the meninges, may occur sporadically, or in association with the inherited disorder, neurofibromatosis 2 (NF2). Most sporadic meningiomas result from NF2 inactivation, resulting in loss of tumor suppressor merlin, implicated in regulating membrane-cytoskeletal organization. To investigate merlin function in an authentic target cell type for NF2 tumor...

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Identifiers

PMID: 17962031
DOI: 10.1016/j.nbd.2007.09.002
PMCID: PMC2266821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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