Article
Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.
Japanese journal of cancer research : Gann - 1 Oct 1996
Imai Y, Oda H, Arai M, Shimizu S, Nakatsuru Y, Inoue T, Ishikawa T
Abstract excerpt
Because combined hepatocellular-cholangiocellular carcinoma is rare and its biological features and pathogenesis have not been well established, we investigated alterations of the p53, K-ras and Rb-1 genes, as well as expression patterns of carcinoembryonic antigen and keratin, in seven combined...
Topics
- Aged
- Alleles
- Carcinoembryonic Antigen
- Carcinoma, Hepatocellular
- Cholangiocarcinoma
- DNA Mutational Analysis
- Female
- Gene Deletion
- Genes, Retinoblastoma
- Genes, p53
- Genes, ras
- Humans
- Keratins
- Liver Neoplasms