Article
Clinical and molecular analysis of combined hepatocellular-cholangiocarcinomas.
Journal of hepatology - 1 Aug 2004
Cazals-Hatem Dominique, Rebouissou Sandra, Bioulac-Sage Paulette, Bluteau Olivier, Blanché Hélène, Franco Dominique, Monges Geneviève, Belghiti Jacques, Sa Cunha Antonio, Laurent-Puig Pierre, Degott Claude, Zucman-Rossi Jessica
Abstract excerpt
BACKGROUND/AIMS: Combined hepatocellular-cholangiocarcinoma (HCC-CC) show dual hepatocellular and biliary epithelial differentiation. To better understand the relations between cholangiocarcinoma (CC), HCC-CC and hepatocellular carcinoma (HCC), we screened for genetic alterations. METHODS: A series of nine CC, 15 HCC-CC and three separated HCC and CC lesions ('collision tumors') were screened for loss of...
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